PGS (preimplantation genetic screening) is a genetic test to select genetically healthy embryos to increase the chances of IVF success. In this test, embryo biopsy is done either on day 3 or day 5 of egg retrieval in IVF procedure. It gives the information about the genetic makeup of the embryos and help to select the best embryos from all for transfer and increases the chances of achieving a successful healthy pregnancy.
PGS works by looking at the type of genetic material within the IVF embryos. These genetic materials are housed within structures called chromosomes. There are 46 Chromosomes in each individual and are very important for the growth and development of the healthy embryo.
Embryos with an incorrect number of the chromosomes called aneuploid embryo typically do not result in a successful pregnancy or it may lead to the birth of the child with genetic abnormality. The embryos with a correct number of chromosomes are called euploid embryos has a better chance of leading to a successful pregnancy.
PGS categorize embryos with the correct number of chromosomes so that one can select the embryos with the finest chances of leading to IVF success.
PGS is appropriate for the vast majority of people undergoing IVF:
– Especially elderly women,
– In cases where history of miscarriages ls present
– In IVF failures patients.
All women are at the risk of producing chromosomally abnormal embryos. As the woman age increases the possibility for chromosomally abnormal embryos also increases.
PGS is such a blessing that helps women of all ages increases their chances of a successful pregnancy.
Benefits of PGS:
- Higher the chances of pregnancy
- Reduces the risk of miscarriage
- More reassurance in transferring a single healthy embryo, avoiding health risk associated with twin or triplet pregnancies.
- Reduced number of IVF cycles required to achieve pregnancy, potentially also reducing the time and the cost of extra cycles.
Generally, the most superior embryo screening technology providing a complete picture of chromosomal health is used.
The PGS result will fall into one of these three categories:
Euploid, Aneuploid or Mosaic.
The information derived from the screening is good enough to help the care team to select the best of all the embryos for transfer.
Risk of PGS
- PGS requires IVF which involves risk of ovarian hyperstimulation syndrome and multiple pregnancies.
- False negative result could mean an abnormal embryo is transferred to the uterus, which may result in negative outcome or miscarriage, limiting the chance of healthy pregnancy.
- Test could result in no embryo to transfer also.
- Screening for all possible genetic disease or disorder is not possible.
PGS is a blessing that helps women of all ages increasing their chances of having a successful pregnancy upto 60%.