Does Personalised Embryo Transfer Improves IVF Success Rate

Many women who try to conceive through IVF may fail the embryo implantation process (embryos getting attached to the uterus) even when the embryos appear healthy and the endometrium appears good by ultrasound.  Implantation is a complex process which requires presence of a healthy embryo, a receptive endometrium (lining of uterus ready to hold the pregnancy) and a synchronised molecular dialogue between the two.

It is now possible to determine how receptive is a woman’s uterus to the embryos.  The test called Endometrial Receptivity Array (ERA) not only measures the receptivity of the uterus, but also helps to determine the exact time for embryo transfer which offers the best chances of success.

The ERA test examines the endometrial receptivity as a product of gene expression of the endometrial lining at specific times.  It monitors cyclical pattern of 238 different genes and determines a personalized period of implantation for each patient i.e estimating the day on which embryo transfer will be successful .

ERA has shown a high sensitivity and specificity in detecting gene expression profiles associated with receptivity .

This has tremendous benefits to the patient as it saves on time, reduces the  number of IVF cycles a couple has to undergo and making sure the embryo is implanted in the personalised window of time for that particular patient to achieve successful pregnancy. Its a simple OPD procedure.

A recent study presented by Professor Carlos Simon established that the personalised Embryo Transfer guided by ERA improves the IVF outcome compared to fresh embryo transfer or Deferred Embryo Transfer.

If ERA test report shows non receptive endometrium than, either the test is repeated or option for surrogacy is given to the patient.